Novel Secondary Metabolites from Endophytic Marine-derived Fungi
نویسنده
چکیده
The marine-derived fungus Stachylidium sp. was isolated from the sponge Callyspongia cf. C. flammea. Chemical investigation of the bioactive fungal extract led to the isolation of the novel phthalimidine derivatives marilines A D (1-4). The absolute configuration of the enantiomeric compounds 1 and 2 was assigned by means of theoretical Circular Dichroism calculations. The skeleton of marilines A D is most unusual, and its biosynthesis is suggested to require unusual biochemical reactions in fungal secondary metabolism. Both enantiomers marilines A and B (1, 2) inhibited human leucocyte elastase (HLE) with an IC50 value of 0.86 μM, and acetylcholinesterase (AChE) with IC50 values of 0.18 μM (offset = 49 %) and 0.63 μM (offset = 54 %), respectively. Figure 1. Structural Formulae of Compounds 1 – 4 O N
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